Protein Homeostasis Chaperones
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include SNRPD3 (spliceosomal snRNP D3), PPIA (cyclophilin A, peptidyl-prolyl isomerase/chaperone), PPIB (cyclophilin B, ER chaperone), POLR2J (RNA polymerase II subunit), NAA10 (N-alpha-acetyltransferase, co-translational modification), TBCA (tubulin-specific chaperone A), TUFM (mitochondrial elongation factor Tu), PTPMT1 (mitochondrial phosphatase), HIGD1A (hypoxia-inducible, mitochondrial respiratory complex assembly), PRDX2 (peroxiredoxin 2, antioxidant), SSR2 (signal sequence receptor, translocon), DYNLRB1 (dynein light chain), GMFG (glia maturation factor gamma, actin depolymerization in leukocytes). The module spans RNA splicing, chaperones, mitochondrial function, and protein biogenesis. PPIA and PPIB are classic housekeeping chaperones. This is a general cellular housekeeping/protein homeostasis module without a lineage-specific identity.
Genes
ATXN10, DYNLRB1, GMFG, HIGD1A, NAA10, POLR2J, PPIA, PPIB, PRDX2, PTPMT1, SH3BGRL, SNRPD3, SSR2, TBCA, TUFM
Most correlated modules
- General Housekeeping Mixed · correlation 0.87
- NKG2D Cytotoxic Activation · correlation 0.85
- Basal Cell Maintenance · correlation 0.85
- Cytotoxic Effector Actin · correlation 0.83
- Lymphocyte Homeostatic Regulation · correlation 0.83
- T-bet Effector Differentiation · correlation 0.81
- Glycolysis & Proteasome · correlation 0.81
- Effector Cell Migration · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.