Cytotoxic Effector Actin
Gene co-expression module in Gamma-delta T cells
| Category | cytotoxicity |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 23 genes have a known function matching the annotation |
Why this annotation
This tightly core-coherent module with high mean expression (1.177) and 64% detection contains: CLIC1 (chloride channel/inflammasome), PSMB10 and PSMB9 (immunoproteasome beta subunits, IFN-gamma inducible), NDUFB2/NDUFA12 (mitochondrial Complex I), MYL12B/MYL6 (myosin light chains, cytoskeleton), ARPC5/ARPC2/BRK1 (Arp2/3 complex, actin polymerization), CFL1 (cofilin, actin dynamics), CORO1A (coronin 1A, T-cell actin/immune synapse), RAC2 (Rho GTPase, immune function), PPP1CA (protein phosphatase), TBCB (tubulin folding), TRAPPC1 (vesicle trafficking), SCP2 (lipid transfer), DBI (actin/lipid binding), ATOX1 (copper chaperone), PYCARD (ASC/inflammasome adaptor). The dominant theme is actin cytoskeleton remodeling (ARPC2, ARPC5, BRK1, CFL1, CORO1A, MYL12B, MYL6, RAC2) combined with immunoproteasome activity (PSMB9, PSMB10) and inflammasome components (PYCARD, CLIC1). In gdT cells this pattern is consistent with cytotoxic effector state: actin-based immune synapse formation coupled with antigen processing.
Genes
ARPC2, ARPC5, ATOX1, BRK1, CFL1, CLIC1, CORO1A, DBI, MYL12B, MYL6, NDUFA12, NDUFB2, NDUFB7, PFN1, PPP1CA, PSMB10, PSMB9, PYCARD, RAC2, SCP2, TBCB, TRAPPC1, TWF2
Most correlated modules
- General Housekeeping Mixed · correlation 0.93
- Actin Remodeling · correlation 0.89
- T Cell Homeostasis · correlation 0.87
- Complex I Assembly · correlation 0.85
- Lymphocyte Homeostatic Regulation · correlation 0.84
- Glycolysis & Proteasome · correlation 0.84
- Protein Homeostasis Chaperones · correlation 0.83
- Effector Cell Migration · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.