SSNA1 — SS nuclear autoantigen 1
SSNA1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SSNA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | AP2M1, ATP5MF, ATP6V0B, AURKAIP1, BSG, CALM3, CLTB, CSNK2B +19 more | View in SCUBA |
| CD8⁺ T cells | Metabolic Housekeeping Housekeeping | COX17, DAZAP1, EIF4E, ILF2, MRPL51, NDUFA2, TADA3, TPM4 | View in SCUBA |
| Gamma-delta T cells | General Housekeeping Mixed Housekeeping | ARPC3, CHCHD5, COPZ1, DRAP1, IDH3G, NDUFB10, OSTC, POLR2G +4 more | |
| Innate lymphoid cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ACTR10, ANP32A, APOL3, ATP6V1E1, ECHS1, ERCC1, ETFB, GLRX3 +12 more | View in SCUBA |
| Macrophages | ERAD Proteasome Housekeeping | ADRM1, EIF6, EMC6, GLRX3, GNPTG, LRPAP1, MAP2K2, MED8 +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial Housekeeping Mitochondrial & OxPhos | ARPC3, DUT, GNB2, GPSM3, LSM2, NAA38, NDUFB10, PLEKHJ1 +7 more |
About the gene
| Synonyms | N14, NA14 |
|---|---|
| Chromosome | 9: 137188660-137190370 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Neurogenesis |
Function
Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST. Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules (By similarity). Plays a role in axon outgrowth and branching. Required for cell division.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.