Basal Cell Maintenance
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 18 genes have a known function matching the annotation |
Why this annotation
This module contains a diverse set of housekeeping genes with uniform expression across all subsets. Hub genes include PDAP1 (PDGFA-associated protein), SYNC (syncoilin), CYB561D2 (cytochrome b561), STK25 (serine/threonine kinase), LMF2 (lipase maturation factor), DNAJC8 (HSP40 chaperone), STX10 (syntaxin), UBE2L3 (ubiquitin conjugating enzyme), GPAA1 (GPI anchor attachment), PCYT2 (phospholipid synthesis), OTUB1 (deubiquitinase), PFDN1 (prefoldin chaperone), and SNRPA (snRNA binding). These genes collectively represent basic cellular maintenance functions—ubiquitin-proteasome system, vesicle trafficking, lipid metabolism, chaperone activity, and RNA processing—with no dominant single pathway. This is consistent with a housekeeping/basal cell maintenance module. No lineage contamination signals. Neighbor context: adjacent to similarly housekeeping-like modules M154 and M174, reinforcing a cluster of constitutive cellular maintenance programs.
Genes
ARHGDIB, CYB561D2, DNAJC8, GPAA1, INO80E, LMF2, MIF4GD, OTUB1, PCYT2, PDAP1, PFDN1, PLEKHJ1, SNRPA, STK25, STX10, SYNC, TBC1D10B, UBE2L3
Most correlated modules
- General Housekeeping Mixed · correlation 0.89
- Transcriptional Elongation Control · correlation 0.89
- Lymphocyte Homeostatic Regulation · correlation 0.88
- Oxidative Phosphorylation · correlation 0.86
- Glycolysis & Proteasome · correlation 0.85
- Mitochondrial Housekeeping · correlation 0.85
- Protein Homeostasis Chaperones · correlation 0.85
- Actin Remodeling · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.