T Cell Phosphatase Signaling
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub PTPN7 is a hematopoietic protein tyrosine phosphatase highly expressed in T cells and involved in TCR signal attenuation and lymphocyte differentiation. YWHAE (14-3-3ε) is a signaling scaffold that interacts with many kinases and phosphatases. PSMD14 is a proteasome-associated deubiquitinase. IFIT3 is an interferon-stimulated gene. ZCCHC8 links to RNA exosome/surveillance. DR1 represses transcription. DNAJB11 is an ER chaperone. SAR1A is a COPII vesicle GTPase. The module is heterogeneous (weak-to-moderate membership for most genes) but PTPN7 as dominant hub with YWHAE, PSMD14 suggests a T-cell signaling/proteostasis program. IFIT3 adds a minor interferon thread. Moderate coherence with PTPN7 as an anchor.
Genes
AMZ2, ASTE1, DNAJB11, DR1, EFCAB2, IFIT3, PSMD14, PTPN7, SAR1A, SMPD4, TOR1AIP1, YWHAE, ZCCHC8
Most correlated modules
- RNA Surveillance/NMD · correlation 0.83
- Mitochondrial RNA Processing · correlation 0.82
- Spliceosome Regulation · correlation 0.79
- Transcriptional Repressor Complex · correlation 0.78
- RNA Binding/Splicing · correlation 0.78
- ER Protein Biogenesis · correlation 0.77
- mRNA Decay Regulation · correlation 0.77
- T Cell Migration · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.