SCUBA

PCF11 — PCF11 cleavage and polyadenylation factor subunit

PCF11 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PCF11's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsmRNA Splicing
RNA processing
AFF4, ARL6IP1, CALR, CCNL1, CLK1, DDX3X, DDX5, EIF4A2 +7 moreView in SCUBA
CD4⁺ T cellsmRNA Splicing Processing
RNA processing
ANXA2R, APOL3, BTN3A1, CCNL1, CHCHD7, CMPK1, DDX5, EIF4A2 +7 moreView in SCUBA
FibroblastsCo-transcriptional RNA Processing
Housekeeping
FUS, IFRD1, INTS6, PPP1R10, RSRP1, TSPYL2, YME1L1View in SCUBA
Gamma-delta T cellsMitochondrial Biogenesis
Mitochondrial & OxPhos
ARFIP1, ARRDC3, COG2, COQ7, DXO, EPM2AIP1, EPS8, HELQ +7 more
Innate lymphoid cellsPyruvate Metabolism
Metabolism
ABCB1, ADI1, ARID1B, ATF7IP2, CFAP298, EIF2AK2, HNRNPH3, MINDY2 +10 moreView in SCUBA
MacrophagesSplicing Factor Regulation
Housekeeping
ARAP1, CCNL1, CELF1, CLK1, FAM53C, IFRD1, INPPL1, KIDINS220 +12 moreView in SCUBA
Mucosal-associated invariant T cellApoptosis Regulation
Immune regulation
ARF4, ARRDC3, CARD8, CFLAR, CREBZF, MAPRE2, NABP1, PPP1R10 +1 more
Natural Killer cellsTranscription Elongation Control
DNA regulation & transcription
C6orf62, FAM53C, FUS, HEXIM1, INTS6, MAT2A, NABP1, PPP1R10 +2 moreView in SCUBA

About the gene

SynonymsKIAA0824
Chromosome11: 83156988-83187451
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Plasma proteins, Predicted intracellular proteins
Biological processmRNA processing

Function

Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.