PHF20L1 — PHD finger protein 20 like 1
PHF20L1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHF20L1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell costimulation TCR/AP1/NFKb pathway | ASH1L, BOD1L1, CCM2, CCR4, CD28, CREBRF, DDX27, ERBIN +10 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Biogenesis Mitochondrial & OxPhos | ARFIP1, ARRDC3, COG2, COQ7, DXO, EPM2AIP1, EPS8, HELQ +7 more | |
| Innate lymphoid cells | Splicing & Transcription RNA processing & translation | ACTR2, BDP1, CDC5L, CYLD, DHX36, FXR1, GPATCH2, MTPN +12 more | View in SCUBA |
| Macrophages | Pre-mRNA Splicing Housekeeping | BCLAF1, CSNK1A1, DDX3X, DDX5, EWSR1, FUS, HNRNPH1, HNRNPH3 +11 more | View in SCUBA |
About the gene
| Synonyms | CGI-72, FLJ13649, FLJ21615, MGC64923, TDRD20B |
|---|---|
| Chromosome | 8: 132775358-132848807 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2. Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.