WSB1 — WD repeat and SOCS box containing 1

WSB1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

WSB1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Antiviral Restriction Anti-viral	FCRL1, GLS, PPM1K, SP100, SP140L, STAT3, TGFB1, TSC22D2 +1 more	View in SCUBA
CD4⁺ T cells	Glucocorticoid Immunoregulation Immune regulation	AHNAK, BTG1, CRIP1, GGNBP2, IDS, INSIG1, IRS2, JUND +11 more	View in SCUBA
Gamma-delta T cells	Mitochondrial Biogenesis Mitochondrial & OxPhos	ARFIP1, ARRDC3, COG2, COQ7, DXO, EPM2AIP1, EPS8, HELQ +7 more
Glial cells	Cytoskeletal Glial Homeostasis Cytoskeletal	ABCA1, ANKRD12, ATP1B1, FERMT2, PHLDB1, PRKCA, TUBA1A, TUBA1B +1 more	View in SCUBA
Macrophages	Splicing Factor Regulation Housekeeping	ARAP1, CCNL1, CELF1, CLK1, FAM53C, IFRD1, INPPL1, KIDINS220 +12 more	View in SCUBA
Monocytes	AP-1 Stress Response Stress	BTG2, FOSB, MYLIP, PLK3, PMAIP1, PPP1R10, PPP1R15B, RGS2 +1 more	View in SCUBA
Mucosal-associated invariant T cell	AP-1 Immediate Early Stress	AMD1, BRD2, CITED2, CSKMT, FUS, GADD45B, GADD45G, H2AX +17 more
Smooth muscle cells	hnRNP & Proteasome RNA processing & translation	ARF1, CCT2, GDI2, HNRNPA2B1, HNRNPA3, HNRNPF, HNRNPU, PSMD8 +2 more	View in SCUBA

About the gene

Synonyms	DKFZp564A122, DKFZp564B0482, SWIP1
Chromosome	17: 27294076-27315926
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins
Biological process	Ubl conjugation pathway

Function

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.