Histone Demethylase Program
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include PSME4 (PA200 proteasome activator, involved in DNA damage response and histone degradation), KDM6A (H3K27me3 demethylase, Polycomb antagonist), CHD6 (chromatin helicase DNA-binding protein), SP3 (transcription factor with chromatin regulatory roles), and RIC1 (Rab6 GEF, Golgi trafficking). Strong coherence. KDM6A and CHD6 are canonical chromatin remodelers; PSME4 links to proteasomal processing of histones. Neighbor M170 also emphasizes chromatin regulation, reinforcing this label. The module likely reflects active chromatin remodeling in gd T cells.
Genes
BLTP3B, CHD6, ESYT2, KDM6A, NECAP1, PI4K2A, PSME4, RAPGEF1, RIC1, SP3, STRAP, TMEM127, USF3
Most correlated modules
- Hypoxia Stress Response · correlation 0.88
- MAPK Kinase Signaling · correlation 0.88
- Chromatin Epigenetic Regulation · correlation 0.85
- Transcriptional Coactivation · correlation 0.85
- Transcription-RNA Coupling · correlation 0.79
- T Cell Maturation · correlation 0.79
- DNA Damage Ubiquitin · correlation 0.79
- Wnt-STAT3 Signaling · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.