MAPK Kinase Signaling
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
Hub gene BRAF (RAF family serine/threonine kinase, MAPK pathway) and MAP3K2 (MEKK2, upstream MAPK kinase) anchor a MAPK signaling theme. DYRK1A (dual-specificity kinase, multiple signaling roles), GNA13 (G-protein alpha subunit, upstream of Rho/MAPK), PPP4R3A (PPP4 phosphatase complex, DNA damage/signaling). CHD1 (chromatin remodeler, transcription regulation), KDM2A (H3K36me2 demethylase), MSL2 (dosage compensation E3 ligase), ARIH1 (RING E3 ligase), SRRM2 (splicing factor). The module blends kinase signaling with chromatin regulation — potentially a transcriptional response downstream of MAPK. CDK16, RNF38, NDEL1 support kinase/regulatory roles. Neighbor M97 also contains kinase-related (FNIP1/AMPK) regulatory factors.
Genes
ARIH1, B4GALT1, BRAF, CDK16, CHD1, DYRK1A, GNA13, KDM2A, MAP3K2, MSL2, NDEL1, PPP4R3A, RELL1, RNF38, SRRM2, TM9SF3, TTC19
Most correlated modules
- Ubiquitin-p53 Regulation · correlation 0.92
- Pre-mRNA Splicing · correlation 0.89
- DNA Damage Ubiquitin · correlation 0.88
- Histone Demethylase Program · correlation 0.88
- Hypoxia Stress Response · correlation 0.88
- Chromatin Epigenetic Regulation · correlation 0.87
- Stress Epigenetic Silencing · correlation 0.85
- Transcriptional Coactivation · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.