T Cell Calcium-Cytoskeletal
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes IQGAP1 (scaffold protein linking cytoskeleton to Rac1/Cdc42 and Ca2+/calmodulin signaling), MAP4 (microtubule-associated protein, stabilizes microtubules), SUPT6H (Spt6 transcription elongation and chromatin factor), TRIM22 (TRIM E3 ligase, antiviral/innate immune), PRKAR1A (PKA type I regulatory subunit, cAMP signaling), TRAPPC11 (TRAPP complex, vesicle trafficking/autophagy), CRACR2A (Ca2+ release-activated Ca2+ channel regulator 2A — lymphocyte-specific, regulates SOCE/NFAT in T cells), IKZF3/Aiolos (Ikaros family transcription factor, lymphocyte development and maturation), GCNT1 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase — required for PSGL-1 modification and T cell tissue homing/trafficking), CASP8 (apoptosis initiation), RFFL (RING finger/FYVE-like E3 ligase). CRACR2A, IKZF3, and GCNT1 are lymphocyte/T cell-specific markers. CRACR2A regulates Ca2+ signaling downstream of TCR activation. IKZF3 regulates T cell differentiation and Th2/effector programs. GCNT1 is required for selectin ligand biosynthesis enabling T cell homing. IQGAP1 and MAP4 contribute cytoskeletal scaffold function. This module reflects T cell-specific regulatory programs integrating calcium signaling, cytoskeletal organization, and transcriptional control relevant to T cell maturation and trafficking.
Genes
CASP8, CRACR2A, GCNT1, IKZF3, IQGAP1, MAP4, PRKAR1A, PSEN1, RFFL, SCRIB, STYX, SUPT6H, TRAPPC11, TRIM22
Most correlated modules
- Rho GTPase Signaling · correlation 0.81
- Actin Cytoskeletal Regulation · correlation 0.80
- Metabolic-Translational Coupling · correlation 0.78
- Chromatin Remodeling Signaling · correlation 0.78
- Spliceosome Regulation · correlation 0.77
- DNA Damage Response · correlation 0.75
- Chromatin TF Regulation · correlation 0.72
- Tissue Resident CD103+ · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.