DNA Damage Response
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 26 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes PCM1 (pericentriolar material, centrosome), CHD8 (chromatin remodeler, associated with transcription and genome stability), ERBIN (ERBB2IP, scaffold), LUC7L2 (splicing factor), LRBA (BEACH domain protein, vesicle/autophagy), DOCK2 (Rac1/2 GEF, lymphocyte chemotaxis), EP400 (NuA4/TIP60 chromatin remodeling complex), MSH6 (DNA mismatch repair), PRKDC (DNA-PKcs, NHEJ DNA repair), SETX (Senataxin, R-loop resolution/transcription-replication conflict), MGA (MAX gene-associated, transcriptional repressor), SIN3A (HDAC co-repressor complex), SYNCRIP (hnRNPQ, RNA processing), RIF1 (DNA repair/replication timing), TRIP12 (E3 ubiquitin ligase, DNA damage response). Strong coherence. Multiple DNA repair factors (PRKDC, MSH6, SETX, RIF1) co-expressed with chromatin remodelers (CHD8, EP400, SIN3A, MGA) and splicing factors (LUC7L2, SYNCRIP). This represents a DNA damage response and genome integrity maintenance program. Neighbor context: complements M173's translational/biosynthetic program — together they reflect anabolic/maintenance state.
Genes
AP1B1, CCAR1, CHD8, DOCK2, EP400, ERBIN, GOLM2, IPO8, LRBA, LUC7L2, MARCHF7, MGA, MSH6, NT5C2, NUP205, PCM1, PCNT, PPP6R3, PRKDC, RIF1, SETX, SIN3A, SYNCRIP, TRIP12, TTC17, UBE4A
Most correlated modules
- Chromatin Epigenetic Regulation · correlation 0.90
- Actin Cytoskeletal Regulation · correlation 0.89
- Chromatin Remodeling · correlation 0.87
- Metabolic-Translational Coupling · correlation 0.87
- mTOR-Exocyst Signaling · correlation 0.84
- Nuclear Pore Organization · correlation 0.84
- Post-transcriptional RNA Regulation · correlation 0.83
- Vesicular Trafficking · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.