Chromatin Remodeling Signaling
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 32 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 32 genes have a known function matching the annotation |
Why this annotation
Hub genes SMARCA2 (SWI/SNF ATPase), NR3C1 (glucocorticoid receptor), TGFBR2 (TGF-β receptor), MAPK1 (ERK2), WNK1 (stress-responsive kinase), CFLAR (caspase regulator), MBNL1 (splicing regulator), CLASP1 (microtubule organizer), and RANBP2 (nuclear pore) collectively define a broad intracellular regulatory state centered on chromatin remodeling and signal transduction. SMARCA2 and NR3C1 point to glucocorticoid-responsive chromatin remodeling; TGFBR2, MAPK1, WNK1, MAP4K5 indicate active signal transduction. The module coherence is strong and all subsets are uniform, consistent with a basal regulatory program in gd_T cells.
Genes
AKAP13, BPTF, CARNMT1, CCDC6, CFLAR, CLASP1, CLASP2, DOCK10, FBXW7, FHIP2A, GOLGB1, GPATCH8, MAP4K5, MAPK1, MBNL1, NR3C1, PCNX1, PCNX4, PRKACB, RANBP2, RIN3, RNF144A, SLC4A7, SLK, SMARCA2, SSH2, ST8SIA4, TGFBR2, TMED5, TMF1, WNK1, ZNF791
Most correlated modules
- mRNA Splicing Regulation · correlation 0.90
- Activation Stress Response · correlation 0.89
- Spliceosome Regulation · correlation 0.89
- Centrosome Organization · correlation 0.84
- NK Receptor Expression · correlation 0.84
- T Cell Migration · correlation 0.84
- TCR Inhibitory Signaling · correlation 0.82
- T Cell Exhaustion · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.