Tissue Resident CD103+
Gene co-expression module in Gamma-delta T cells
| Category | Tissue residence |
|---|---|
| Genes | 37 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 37 genes have a known function matching the annotation |
Why this annotation
ITGAE (CD103) and ITGA1 (CD49a) are the canonical integrin pair defining tissue-resident memory T cells, retaining cells in epithelial tissues via E-cadherin binding. ENTPD1 (CD39) marks tissue-resident and exhausted T cells. TMIGD2 (HHLA2 receptor) is expressed on tissue-infiltrating T cells. UBASH3B attenuates TCR signaling. WASF1, MYO1E, PARVB, and CLIC5 represent actin cytoskeletal remodeling supporting tissue lodging. SRGAP3 regulates Rho GTPases for cell shape. CLNK adapts lymphocyte signaling. GPR34 is expressed on tissue-resident immune cells. This module strongly represents the tissue-residency program with cytoskeletal anchoring.
Genes
ADRB1, BCAS4, BLMH, CCNJL, CD160, CD96, CLIC5, CLNK, DHCR24, ECI2, ELOVL6, ENTPD1, FSD1, GALNT2, GPR34, GPR82, IFITM10, ITGA1, ITGAE, KIAA0513, MAPK11, MAPK12, MPHOSPH9, MYO1E, OXNAD1, PARVB, PNMT, S1PR3, SIRPG, SLC25A15, SRGAP3, TMIGD2, TXK, UBASH3B, VSTM2L, WASF1, ZNF609
Most correlated modules
- Gut-homing Residence · correlation 0.92
- NK Receptor Expression · correlation 0.92
- Hypoxia Tissue Adaptation · correlation 0.91
- Chromatin Repression · correlation 0.91
- Activation Stress Response · correlation 0.86
- Basal Lipid Metabolism · correlation 0.83
- DNA Repair Housekeeping · correlation 0.81
- mRNA Splicing Regulation · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.