GCNT1 — Glucosaminyl (N-acetyl) transferase 1
GCNT1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GCNT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Regulatory T cell Immune regulation | ATP1B1, EBI3, FOXP3, GADD45A, GTF2H5, IL1R1, IL1R2, IPCEF1 +6 more | View in SCUBA |
| Enterocytes | Mitochondrial Energy Metabolism Mitochondrial & OxPhos | ALDH1A1, ALDH3A2, CPS1, GALM, GPI, GSTM4, MTCH2, NDUFV1 +2 more | View in SCUBA |
| Gamma-delta T cells | T Cell Calcium-Cytoskeletal T cell maturation | CASP8, CRACR2A, IKZF3, IQGAP1, MAP4, PRKAR1A, PSEN1, RFFL +5 more | |
| Macrophages | Myeloid Signaling Regulation Innate immunity | ADGRG6, AOAH, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A +38 more | View in SCUBA |
About the gene
| Synonyms | C2GNT, NACGT2, NAGCT2 |
|---|---|
| Chromosome | 9: 76419850-76651203 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Glycosyltransferase that catalyzes the transfer of an N- acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. The catalysis is metal ion- independent and occurs with inversion of the anomeric configuration of sugar donor (By similarity). Selectively involved in synthesis of mucin-type core 2 O-glycans that serve as scaffolds for the display of selectin ligand sialyl Lewis X epitope by myeloid cells, with an impact on homeostasis and recruitment to inflammatory sites (By similarity). Can also act on glycolipid substrates. Transfers GlcNAc moiety to GalGb4Cer globosides in a reaction step to the synthesis of stage- specific embryonic antigen 1 (SSEA-1) determinant (By similarity). Can use Galbeta1-3GalNAcalpha1- and Galbeta1-3GalNAcbeta1- oligosaccharide derivatives as acceptor substrates (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.