NK-like Terminal Differentiation
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
ZEB2 is a master transcription factor driving terminal NK and effector T cell differentiation. FCRL6 marks cytotoxic lymphocytes (NK and terminally differentiated T cells). LILRB1 (ILT2/CD85j) is an inhibitory receptor expressed on terminally differentiated NK/T cells and associated with immune exhaustion or regulation. SYT11 (synaptotagmin) supports vesicle-mediated cytotoxic granule release. EPB41L4A and MLC1 contribute cytoskeletal remodeling. PRR5L (mTORC2 component) ties into metabolic regulation of effector cells. Neighbor context (M155 cytotoxic, M19 terminal differentiation) strongly reinforces a terminally differentiated/NK-like effector identity.
Genes
EPB41L4A, FCRL6, JAZF1, LILRB1, MLC1, PRR5L, SYT11, ZEB2
Most correlated modules
- Cytotoxic Effector Program · correlation 0.88
- Terminal T Differentiation · correlation 0.81
- Tissue-resident gd T · correlation 0.81
- TCR Activation Signaling · correlation 0.75
- TGF-beta Signaling · correlation 0.71
- T Cell Identity Program · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.