TGF-beta Signaling
Gene co-expression module in Gamma-delta T cells
| Category | Immune regulation |
|---|---|
| Genes | 27 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 27 genes have a known function matching the annotation |
Why this annotation
The top hub gene is TGFBR1 (TGF-β receptor type I), with supporting signaling genes including PPP3CC (calcineurin/NFAT pathway), PTPN4 (phosphatase), MAST3 (kinase), STK26, and INPP4A (PI metabolism). Lipid/membrane metabolic genes (PCYT1A, ADIPOR2) and vesicle/trafficking genes (NAPA, ACAP2) are also present. The module is moderately coherent with several weak-membership hub genes, suggesting a mixed regulatory program centered on TGF-β signaling and associated metabolic adaptation in a quiescent γδ T state.
Genes
ABCF1, ABHD12, ACAP2, ADIPOR2, CBX6, ENPP4, FBXO9, GSAP, INPP4A, LRPAP1, MAST3, MBP, MYBL1, NAPA, NUCB1, PARP15, PCYT1A, PLEKHA1, PPP3CC, PTPN4, SAMD9, SLC20A1, STK26, TGFBR1, TINF2, TPP1, TRIM8
Most correlated modules
- ER-Lysosomal Trafficking · correlation 0.83
- Antiviral ISG Response · correlation 0.82
- TCR-Cytokine Signaling · correlation 0.81
- Lymphocyte Homeostatic Regulation · correlation 0.81
- γδ T Cell Identity · correlation 0.77
- Butyrophilin gd Activation · correlation 0.76
- Chromatin Epigenetic Regulation · correlation 0.76
- Cytotoxic Effector Program · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.