LILRB1 — Leukocyte immunoglobulin like receptor B1
LILRB1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LILRB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NK-like Terminal Differentiation T cell maturation | EPB41L4A, FCRL6, JAZF1, MLC1, PRR5L, SYT11, ZEB2 | |
| Macrophages | Anti-inflammatory Response Inflammatory | AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, CITED2, DENND3 +31 more | View in SCUBA |
| Monocytes | IFN-gamma Monocyte Activation Inflammatory | BLVRA, CYB5A, DRAP1, FCGR1A, GAS6, HLA-F, IFITM3, LGALS9 +3 more | View in SCUBA |
About the gene
| Synonyms | CD85, CD85j, ILT2, LIR-1, LIR1, MIR-7, PIR-B, PIRB |
|---|---|
| Chromosome | 19: 54617158-54638022 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide. Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells. Reprograms B cells toward an immune suppressive phenotype.
Human Protein Atlas · Open Targets
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.