TCR Activation Signaling
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes ITGAL (LFA-1 integrin), NFATC3 (NFAT TF), PLCB2 (PLC-beta, TCR downstream), ADCY7 (adenylyl cyclase), STK10 (lymphocyte-oriented kinase), DIAPH1 (actin nucleation via formin), and CYFIP2 (WAVE complex, actin dynamics) collectively describe TCR-coupled signaling driving integrin activation and actin remodeling — canonical T cell activation and adhesion program. NBEAL2 (dense granule biogenesis) fits effector T cell context.
Genes
ADCY7, ATP2B4, CYFIP2, DIAPH1, GK5, GLG1, ITGAL, NBEAL2, NFATC3, PLCB2, PSAP, RNF213, STK10
Most correlated modules
- Butyrophilin gd Activation · correlation 0.91
- TGF-β Migration Program · correlation 0.89
- T Cell Identity Program · correlation 0.87
- ER Antigen Processing · correlation 0.82
- γδ T Cell Identity · correlation 0.82
- ER Glycoprotein Quality Control · correlation 0.81
- Vesicular Trafficking · correlation 0.80
- Antiviral ISG Response · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.