Cytotoxic Effector Program
Gene co-expression module in Gamma-delta T cells
| Category | cytotoxicity |
|---|---|
| Genes | 23 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 23 genes have a known function matching the annotation |
Why this annotation
This module is a highly coherent, canonical cytotoxic effector signature. Core hub genes include GZMH and GZMB (granzymes), PRF1 (perforin), GNLY (granulysin), FGFBP2 (marker of terminally differentiated cytotoxic T/NK), FCGR3A (CD16), CX3CR1 (marks circulating cytotoxic effectors), ADGRG1 (GPR56, tissue-homing effector marker), and PRSS23 (serine protease). ITGB1 and CADM1 support adhesion/migration of effectors. This program is consistent with terminally differentiated cytotoxic γδ T cells co-expressing NK-like effector machinery.
Genes
ADGRG1, ANXA4, CADM1, CX3CR1, FCGR3A, FGFBP2, FGL2, GNLY, GZMB, GZMH, ITGB1, MTSS1, PCDH1, PRF1, PRSS23, RAP1B, RGS9, RHOBTB3, SLCO4C1, SPON2, ST8SIA6, TTC38, ZNF600
Most correlated modules
- Tissue-resident gd T · correlation 0.95
- NK-like Terminal Differentiation · correlation 0.88
- γδ T Cell Identity · correlation 0.84
- Terminal T Differentiation · correlation 0.80
- TGF-beta Signaling · correlation 0.75
- Cytotoxic Effector Program · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.