SYT11 — Synaptotagmin 11
SYT11 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SYT11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | MAF regulatory program Immune regulation | AKAP13, ARID4B, DTHD1, FYN, IKZF3, ISCU, LIMA1, LIMS1 +12 more | View in SCUBA |
| Endothelial | Inflammatory Angiogenesis Inflammation | AZIN1, DHH, FBLN5, FILIP1L, GJA5, ITSN2, NUDT4, OCIAD2 +6 more | View in SCUBA |
| Gamma-delta T cells | NK-like Terminal Differentiation T cell maturation | EPB41L4A, FCRL6, JAZF1, LILRB1, MLC1, PRR5L, ZEB2 | |
| Glial cells | Glial Adhesion Identity migration & adhesion | ADAM23, CADM4, CALU, DAG1, HMCN1, HMGN1, ITGA2, PTPRZ1 +2 more | View in SCUBA |
| Macrophages | Monocyte Phagocytic Identity Lysosomal & pahgocytosis | CD14, CD99, CMTM3, DUSP3, FCGR2A, FLOT2, INF2, MARVELD1 +7 more | View in SCUBA |
| Natural Killer cells | NK Activation Signaling activation | C12orf75, F2R, GRAP2, GZMH, LIME1, LYAR, RGS9, SSBP3 +1 more | View in SCUBA |
About the gene
| Synonyms | DKFZp781D015, KIAA0080, MGC10881, MGC17226 |
|---|---|
| Chromosome | 1: 155859567-155885199 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin- mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.