MAZ — MYC associated zinc finger protein

MAZ belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MAZ's module in each cell type

Cell type	Module	Shares the module with
CD8⁺ T cells	Nuclear RNA Splicing RNA processing & translation	CBX3, DNAJC8, HNRNPA3, HNRNPD, HNRNPR, PGP, PPIG, PSMD1 +5 more	View in SCUBA
Gamma-delta T cells	Polycomb Transcriptional Control DNA/chromatin regulation	AMFR, ATMIN, BRD7, CBX4, CCNY, CD81, CDK2AP1, CSNK1E +17 more
Goblet cells	Mitochondrial OxPhos Mitochondrial & OxPhos	CYC1, NAA38, NDUFV1, PFKL, PPP1R1B, PXMP2, TECR	View in SCUBA
Macrophages	RNA Processing & Repair Housekeeping	BRD7, CCDC59, CCT4, CCT6A, CNDP2, EIF3J, EIF5B, EMC4 +31 more	View in SCUBA
Mucosal-associated invariant T cell	PI3K MAPK Signaling TCR Signaling	AKT1, APH1A, BRD4, CALM2, CMTM3, DAZAP1, GNAS, GRK2 +11 more

About the gene

Synonyms	Pur-1, ZF87, Zif87, ZNF801
Chromosome	16: 29806106-29811164
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding, RNA-binding
Biological process	Transcription, Transcription regulation

Function

Transcriptional regulator, potentially with dual roles in transcription initiation and termination. Binds DNA and functions as a transcriptional activator. Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Binds DNA and functions as a transcriptional activator. Inhibits MAZ isoform 1-mediated transcription. Binds DNA and functions as a transcriptional activator

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.