Innate Stress Signaling
Gene co-expression module in Gamma-delta T cells
| Category | Inflammation |
|---|---|
| Genes | 32 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 32 genes have a known function matching the annotation |
Why this annotation
IRAK1 is a key kinase in TLR/IL-1R innate signaling. MAP2K3 (MKK3) activates p38 MAPK downstream of stress and inflammatory cytokines. TNFRSF1B encodes TNFR2, a TNF receptor mediating inflammatory and survival signals. BCR here likely acts as a scaffold in signaling. PTP4A2 is a phosphatase involved in cytokine signaling. LPCAT1 participates in lipid remodeling during inflammation. HLA-F is an MHC class I molecule. RNF166 is an E3 ubiquitin ligase involved in innate immune signaling. Together these suggest an innate-like inflammatory stress signaling program in gd T cells, consistent with their innate-like nature.
Genes
AKT3, B4GALT4, BCR, BLOC1S4, COL6A2, CREBRF, DGKQ, ELF2, FAM53B, FBXL15, GLTP, GTPBP6, HLA-F, IQGAP2, IRAK1, LPCAT1, MAP2K3, NSMF, OSBPL7, PDZD4, PPP2R5C, PRKCB, PTP4A2, RAB9A, RNF166, SIRT2, SLC44A2, TCF25, TMEM181, TNFRSF1B, TPRG1L, TRAPPC10
Most correlated modules
- T Cell Exhaustion · correlation 0.82
- Terminal T Differentiation · correlation 0.82
- gd T Cell Identity · correlation 0.78
- ER Protein Translocation · correlation 0.75
- mRNA Splicing Processing · correlation 0.75
- Cytotoxic Effector Program · correlation 0.74
- Circadian Clock · correlation 0.74
- TCR-Cytokine Signaling · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.