SPEN — Spen family transcriptional repressor
SPEN belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPEN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Transcriptional Coactivation DNA/chromatin regulation | ATN1, ATP13A3, ATP1A1, CREBBP, FAM76B, GAK, GALNT1, MDM2 +12 more | |
| Lymphatic endothelial | DNA Damage Apoptosis DNA/chromatin regulation | AZIN1, BAZ1A, HNRNPC, IVNS1ABP, MAPK6, OTUD4, PHLDB2, STX3 +4 more | View in SCUBA |
| Macrophages | Transcriptional Repression Housekeeping | AKAP8, ANKRD11, ARIH2, BACH1, CCNT2, CDK13, CEP95, CSNK1D +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | RUNX3 Tissue Identity T cell maturation | B4GALT1, CD44, CDK17, CHD1, CYLD, EML4, EP300, GPBP1 +10 more |
About the gene
| Synonyms | KIAA0929, MINT, RBM15C, SHARP |
|---|---|
| Chromosome | 1: 15836095-15940456 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Activator, DNA-binding, Repressor, RNA-binding |
| Biological process | Host-virus interaction, Notch signaling pathway, Transcription, Transcription regulation |
Function
May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2- mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.