Proteasome Complex
Gene co-expression module in Gamma-delta T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
The top hub genes are predominantly proteasome subunits: PSMD8, PSMC1, PSMC4, PSMC3 (19S regulatory particle ATPases), PSMB6, PSMB7 (20S core beta subunits), covering both the regulatory and catalytic components. Supporting genes include spliceosome (PUF60, SF3B4) and translation (EIF3I) factors reflecting co-regulated housekeeping machinery. Moderate coherence reflects mixture of proteasome with splicing/translation subprograms. Neighbor context (M65: splicing/proteasome, M66: ETC) confirms housekeeping neighborhood.
Genes
APH1A, EIF3I, JTB, MRPL27, PSMB6, PSMB7, PSMC1, PSMC3, PSMC4, PSMD8, PUF60, RAB1B, SF3B4
Most correlated modules
- Transcriptional Elongation Control · correlation 0.86
- Basal Cell Maintenance · correlation 0.84
- Endosomal Vesicle Trafficking · correlation 0.83
- snRNP Splicing · correlation 0.81
- Mitochondrial ETC · correlation 0.80
- Chaperone Protein Folding · correlation 0.78
- mRNA Splicing · correlation 0.77
- Interferon Stimulated Response · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.