mRNA Splicing
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 23 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by spliceosome and RNA-binding proteins: SF3B2 (U2 snRNP), U2AF2 (U2AF65, splice site recognition), RNPS1 (splicing activator), SNW1 (splicing/transcription coactivator), HNRNPM and HNRNPR (hnRNP family), EWSR1 (FUS/EWS/TAF15 family RNA binding), SERBP1 (PABP-interacting RNA processing), and XRCC6 (Ku70, DNA repair). The core program is pre-mRNA splicing. GTF2F1 (TFIIF) links to transcription. Moderate coherence reflects slight admixture of DNA repair (XRCC6) and proteasome (PSMD2, PSMA3) genes. Neighbor modules share nuclear/RNA themes confirming this is a housekeeping splicing program.
Genes
ARHGDIA, DDX27, DDX59, EIF2AK1, EWSR1, FBXL5, GNL1, GTF2F1, HNRNPM, HNRNPR, NOP56, POLE3, PSMA3, PSMD2, RNPS1, SERBP1, SF3B2, SNW1, SZRD1, TPM3, U2AF2, UBA2, XRCC6
Most correlated modules
- Chromatin Remodeling · correlation 0.80
- Proteasome Complex · correlation 0.77
- Nuclear Pore Organization · correlation 0.77
- ER Protein Biogenesis · correlation 0.76
- RNA Splicing Processing · correlation 0.76
- ER Glycoprotein Quality Control · correlation 0.72
- Mitotic Spindle · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.