JTB — Jumping translocation breakpoint
JTB belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
JTB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | AP2M1, ATP5MF, ATP6V0B, AURKAIP1, BSG, CALM3, CLTB, CSNK2B +19 more | View in SCUBA |
| Gamma-delta T cells | Proteasome Complex Protein processing & ER | APH1A, EIF3I, MRPL27, PSMB6, PSMB7, PSMC1, PSMC3, PSMC4 +4 more | |
| Goblet cells | ERAD ER Homeostasis Protein processing & ER | ARF4, ATP2A2, C1orf122, DNAJB9, HERPUD1, LARP1B, PGM3, SELENOK +1 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Lysosomal Housekeeping Mitochondrial & OxPhos | BTF3L4, C14orf119, EMC6, ETFA, IER3IP1, LAMP1, MRPL14, MRPS16 +7 more | View in SCUBA |
| Macrophages | Mixed Housekeeping Housekeeping | AP2M1, BAG1, CHMP4A, CISD2, COA6, CSNK2B, CYB5R3, DEGS1 +20 more | View in SCUBA |
About the gene
| Synonyms | hJT, PAR |
|---|---|
| Chromosome | 1: 153974269-153977674 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted membrane proteins |
| Biological process | Apoptosis, Cell cycle, Cell division, Mitosis |
Function
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.