Interferon Stimulated Response
Gene co-expression module in Gamma-delta T cells
| Category | Inflammation |
|---|---|
| Genes | 15 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 2 of 15 genes have a known function matching the annotation |
Why this annotation
The top hub IFI16 is a well-established interferon-inducible innate immune sensor (cytosolic DNA sensor, inflammasome component) and a canonical interferon-stimulated gene (ISG). EPSTI1 is also a strongly interferon-stimulated gene. Together these two anchor an interferon-response identity. However, the module has only moderate coherence, with many weak/moderate membership scores for other genes (USP5, GUSB, KATNBL1, CTNNBL1, MFAP1, PSMG3), which are functionally diverse (deubiquitylation, lysosomal hydrolase, microtubule, spliceosome, proteasome assembly). AP2A1 links to the M23 trafficking neighbor. The IFI16/EPSTI1 signal is the most specific biologically interpretable program, and the remaining genes likely reflect co-regulated housekeeping in interferon-activated cells. MRPS11 and EXOSC8 may reflect post-transcriptional regulation of ISG mRNAs. Classified as interferon response given the two strongest hub anchors, with caveat of mixed coherence.
Genes
AK3, AP2A1, CTNNBL1, CYB5R3, DRG2, EPSTI1, EXOSC8, GPANK1, GUSB, IFI16, KATNBL1, MFAP1, MRPS11, PSMG3, USP5
Most correlated modules
- Cellular Homeostasis · correlation 0.86
- mRNA Splicing · correlation 0.85
- Chromatin Architecture · correlation 0.85
- DNA Damage Repair · correlation 0.84
- Mitotic Spindle · correlation 0.83
- Endosomal Vesicle Trafficking · correlation 0.82
- Mitochondrial ETC · correlation 0.80
- Transcriptional Elongation Control · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.