PUF60 — Poly(U) binding splicing factor 60
PUF60 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PUF60's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Protein/ER secretory machinery Protein processing & ER | ACTR2, ATP5IF1, ATP5ME, BAZ1B, CMC2, CNPY2, COMMD3, COPZ1 +16 more | View in SCUBA |
| CD8⁺ T cells | ER Protein Quality Control Protein processing & ER | ARPC3, CALR, DYNLL1, MRPL47, PDIA3, PPIB, PSMA5, PSMB1 +3 more | View in SCUBA |
| Gamma-delta T cells | Proteasome Complex Protein processing & ER | APH1A, EIF3I, JTB, MRPL27, PSMB6, PSMB7, PSMC1, PSMC3 +4 more | |
| Glial cells | Rho GTPase Signaling Housekeeping | BRK1, COMMD6, GAPDH, MORF4L1, MRFAP1, NDFIP1, OAZ1, PRDX1 +5 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial OxPhos Biogenesis Mitochondrial & OxPhos | AP1S1, ATOX1, ATP5ME, ATP5MF, C1QBP, CNIH1, CYC1, ERH +22 more | View in SCUBA |
| Macrophages | RNA Processing & Repair Housekeeping | BRD7, CCDC59, CCT4, CCT6A, CNDP2, EIF3J, EIF5B, EMC4 +31 more | View in SCUBA |
About the gene
| Synonyms | FIR, RoBPI, SIAHBP1 |
|---|---|
| Chromosome | 8: 143816344-143830709 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Molecular function | DNA-binding, Repressor, Ribonucleoprotein, RNA-binding |
| Biological process | Apoptosis, mRNA processing, mRNA splicing, Transcription, Transcription regulation |
Function
DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.