EIF3I — Eukaryotic translation initiation factor 3 subunit I
EIF3I belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EIF3I's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Glycolysis Biosynthesis Mitochondrial & OxPhos | FABP5, LDHA, MDH1, MRPL17, PAICS, PKM, POLD2, PRDX1 +4 more | View in SCUBA |
| CD8⁺ T cells | RNA Splicing Complex RNA processing & translation | ATP6V0B, ATP6V1F, MRPS6, NDUFS7, PARK7, PRDX6, PSMD4, SF3B5 +3 more | View in SCUBA |
| Endothelial | Spliceosome snRNP Assembly RNA processing & translation | BAX, CBX3, CCT2, CCT4, FGFR1, HNRNPAB, HNRNPC, NAP1L1 +6 more | View in SCUBA |
| Gamma-delta T cells | Proteasome Complex Protein processing & ER | APH1A, JTB, MRPL27, PSMB6, PSMB7, PSMC1, PSMC3, PSMC4 +4 more | |
| Innate lymphoid cells | Mixed Proteostasis Metabolism Metabolism | ADRM1, ANXA11, ATP6V0B, CISD2, COX17, DNAJC8, DR1, HPRT1 +18 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ACP1, ARPC5L, ATP6V1G1, AURKAIP1, C19orf53, CHMP2A, CIAO2B, CIB1 +31 more | View in SCUBA |
About the gene
| Synonyms | eIF3-beta, eIF3-p36, EIF3S2, TRIP-1 |
|---|---|
| Chromosome | 1: 32221077-32245397 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Initiation factor |
| Biological process | Protein biosynthesis |
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.