ENS Developmental TFs
Gene co-expression module in Glial cells
| Category | Development |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
ERBIN interacts with ErbB2/neuregulin receptors critical for ENS glial differentiation. HAND2 is a core transcription factor for enteric nervous system development, expressed in enteric neurons and glia. TBX3 and TSC22D1 are developmental transcription factors. MAP4K4 is a stress-activated kinase involved in developmental signaling. LRRC4C is a synaptic leucine-rich repeat protein. Module has moderate coherence with several weak members (TUBB2A, SEC11C). Significantly decreased in UC inflammation and recovers in remission, consistent with a developmental/identity TF program suppressed during colitis.
Genes
ERBIN, FRMD3, HAND2, LRRC4C, MAP4K4, PYGL, SEC11C, SLC25A36, TBX3, TSC22D1, TUBB2A
Most correlated modules
- Enteric Glial Homeostasis · correlation 0.81
- Glial Neuroprotective Response · correlation 0.78
- Hyaluronan-CD44 Remodeling · correlation 0.71
- Glial RNA Homeostasis · correlation 0.68
- Inflammatory Activation Response · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.