Glial Progenitor Identity
Gene co-expression module in Glial cells
| Category | Development |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub gene SNAI1 (Snail) is a master EMT transcription factor and developmental regulator; DLX2 is a homeobox TF important in neural/glial development; ID2 and ID4 are inhibitor of differentiation HLH factors crucial for glial progenitor identity and myelination repression; MYLIP (MIB2/IDOL) regulates LDL receptor and has roles in Wnt signaling; RGS2 is a G-protein signaling regulator; MARCKSL1 is a cytoskeletal/membrane protein expressed in neural progenitors; IER5L is an immediate-early response gene. The combination of SNAI1, DLX2, ID2, ID4, and MARCKSL1 points to a glial progenitor or developmental identity program, possibly reflecting undifferentiated or dedifferentiating glia. The down-regulation during inflammation and recovery in remission is consistent with suppression of a developmental/progenitor state during active disease.
Genes
DLX2, ID2, ID4, IER5L, MARCKSL1, MYLIP, RGS2, SNAI1
Most correlated modules
- Anti-proliferative mRNA Decay · correlation 0.92
- DNA Damage Response · correlation 0.91
- Hypoxia mTOR Stress · correlation 0.83
- Glucocorticoid Stress Recovery · correlation 0.82
- RNA Splicing Processing · correlation 0.81
- Integrated Stress Response · correlation 0.81
- Integrated Stress Response · correlation 0.79
- Immediate Early Gene Response · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.