Integrated Stress Response
Gene co-expression module in Glial cells
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes EGR2, EGR3, and CSRNP1 are canonical immediate-early transcription factors induced by stress, growth signals, or inflammatory stimuli. CDKN1A (p21) and MCL1 are stress-survival and cell cycle arrest genes. BAG3 is a chaperone-assisted selective autophagy protein induced under proteotoxic stress. DDIT3 (CHOP) is a hallmark ER/integrated stress response TF. PFKFB3 is induced by hypoxia and metabolic stress. ANKRD37 is a hypoxia-inducible gene. MIDN and MYADM are also stress-responsive. SEMA4A has roles in immune regulation. The module is core-coherent with uniform expression and shows increase in CD inflammation and UC remission, consistent with a stress/damage-response program active in subsets of glia during disease. The combination of EGR TFs, DDIT3, CDKN1A, BAG3, and PFKFB3 points to an integrated stress response.
Genes
ANKRD37, BAG3, CDKN1A, CSRNP1, DDIT3, EGR2, EGR3, MCL1, MIDN, MYADM, PFKFB3, SEMA4A
Most correlated modules
- Integrated Stress Response · correlation 0.96
- DNA Damage Response · correlation 0.93
- COX-2/NF-κB Inflammation · correlation 0.92
- Proteostasis Stress Response · correlation 0.89
- Glucocorticoid Stress Recovery · correlation 0.88
- Anti-proliferative mRNA Decay · correlation 0.86
- Immediate Early Gene Response · correlation 0.85
- RNA Splicing Processing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.