SNAI1 — Snail family transcriptional repressor 1
SNAI1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SNAI1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | NF-κB Early Response Inflammation | BCL3, BHLHE40, ICAM1, INSIG1, ITPKC, KLF10, LDLR, MYADM +3 more | View in SCUBA |
| Fibroblasts | Hypoxia-driven EMT Stress | ARC, CITED2, CSKMT, DDIT4, FAM43A, FAM53C, HBEGF, HEXIM1 +7 more | View in SCUBA |
| Gamma-delta T cells | AP-1 Immediate Early Response Stress | BRD2, CITED2, CSKMT, EGR1, EIF4A2, FRAT1, FRAT2, GADD45B +25 more | |
| Glial cells | Glial Progenitor Identity Development | DLX2, ID2, ID4, IER5L, MARCKSL1, MYLIP, RGS2 | View in SCUBA |
| Macrophages | Integrated Stress Response Stress | AKAP17A, ANKHD1, APBB3, C15orf39, CSF2RA, DDIT3, DDX39B, EMD +17 more | View in SCUBA |
| Monocytes | Inflammatory Stress Response Stress | ARL5B, ATF3, CCRL2, CD83, DUSP10, IL1B, NFE2L2, RASGEF1B +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | AP-1 Immediate Early Stress | AMD1, BRD2, CITED2, CSKMT, FUS, GADD45B, GADD45G, H2AX +17 more | |
| Pericytes | EMT-like Remodeling ECM remodeling | APOLD1, B3GNT5, C2CD4B, CFAP20, FAM43A, INSIG1, LDLR, RALGDS +2 more | View in SCUBA |
About the gene
| Synonyms | SLUGH2, SNA, SNAH, SNAIL, SNAIL1 |
|---|---|
| Chromosome | 20: 49982980-49988886 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Developmental protein, DNA-binding |
Function
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription. SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.