Anti-proliferative mRNA Decay
Gene co-expression module in Glial cells
| Category | Stress |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
Highly coherent module with all genes as core members. ZFP36L1 and ZFP36L2 (TTP family mRNA destabilizers, anti-proliferative), TOB1 (anti-proliferative, mRNA deadenylation), GADD45A (DNA damage/growth arrest), PLK2 (stress-induced kinase), TSPYL2 (growth suppressor), BCL6 (transcriptional repressor), FUS (RNA binding), MAT2A (one-carbon metabolism), RBBP6 (RNA processing), ABHD5 (lipid signaling), EIF4A1 (translation). The ZFP36L1/L2-TOB1-GADD45A axis forms a strong anti-proliferative/mRNA stability program. Very large increase in UC remission (0.748), decrease in CD remission (-0.571). Neighbors M24 (ZFP36) and M50 (ATF3/stress) support stress-induced growth arrest context.
Genes
ABHD5, BCL6, EIF4A1, FUS, GADD45A, MAT2A, PLK2, RBBP6, TOB1, TSPYL2, ZFAND5, ZFP36L1, ZFP36L2
Most correlated modules
- DNA Damage Response · correlation 0.96
- Glial Progenitor Identity · correlation 0.92
- Glucocorticoid Stress Recovery · correlation 0.91
- RNA Splicing Processing · correlation 0.91
- Hypoxia mTOR Stress · correlation 0.89
- Integrated Stress Response · correlation 0.87
- Integrated Stress Response · correlation 0.86
- Immediate Early Gene Response · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.