RNA Splicing Processing
Gene co-expression module in Glial cells
| Category | RNA processing & translation |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
The top hub genes SFPQ, HNRNPA2B1, HNRNPH1, HNRNPAB, and HNRNPDL are all heterogeneous nuclear ribonucleoproteins involved in RNA splicing, processing, and export. DDX3X and DDX5 are DEAD-box RNA helicases central to mRNA metabolism and splicing regulation. These constitute a clear RNA processing core. NES (nestin) is an intermediate filament expressed in progenitor/reactive glia. RND3 is a Rho GTPase involved in cytoskeletal organization. THBS1 (thrombospondin-1) is an ECM glycoprotein with roles in glial signaling. MAFB is a transcription factor. The dominant signal is RNA processing via multiple HNRNPs and RNA helicases; this module likely reflects active RNA metabolism in a glial subpopulation. The decrease during inflammation is consistent with reduced homeostatic RNA processing in disease.
Genes
DDX3X, DDX5, HNRNPA2B1, HNRNPAB, HNRNPDL, HNRNPH1, MAFB, NES, RND3, SFPQ, THBS1
Most correlated modules
- Anti-proliferative mRNA Decay · correlation 0.91
- Proteostasis Stress Response · correlation 0.86
- DNA Damage Response · correlation 0.85
- Glucocorticoid Stress Recovery · correlation 0.82
- Glial Progenitor Identity · correlation 0.81
- Integrated Stress Response · correlation 0.81
- Integrated Stress Response · correlation 0.78
- COX-2/NF-κB Inflammation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.