DNA Damage Response
Gene co-expression module in Glial cells
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Core-coherent module with GADD45B (DNA damage/growth arrest), ING1 (p53 pathway tumor suppressor), IER5 (immediate early stress), NFKBIZ (IκBζ, NF-κB modulator), UBE2S (ubiquitin E2), BRD2 (bromodomain), SRSF3 (splicing), PABPC1 (translation), TUBB4B (cytoskeletal). The stress-response axis (GADD45B, ING1, IER5) dominates hub positions. FAM53C function is less defined. Elevated in UC remission. Neighborhood context (between M36 proteostasis and M25/M30 growth arrest modules) supports a DNA damage/growth arrest stress label.
Genes
BRD2, FAM53C, GADD45B, IER5, ING1, NFKBIZ, PABPC1, SRSF3, TUBB4B, UBE2S
Most correlated modules
- Integrated Stress Response · correlation 0.96
- Anti-proliferative mRNA Decay · correlation 0.96
- Integrated Stress Response · correlation 0.93
- Glucocorticoid Stress Recovery · correlation 0.93
- Immediate Early Gene Response · correlation 0.92
- Glial Progenitor Identity · correlation 0.91
- Proteostasis Stress Response · correlation 0.85
- RNA Splicing Processing · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.