Immediate Early Gene Response
Gene co-expression module in Glial cells
| Category | Activation |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
Highest mean expression (2.428) and pct positive (76.3%) in the batch. All genes are core members. FOS, FOSB, JUN, JUNB (AP-1 transcription factors), EGR1 (early growth response), IER2 (immediate early response), ZFP36 (TTP mRNA destabilizer, connects to M25's ZFP36L1/L2), HES1 (Notch effector), combined with HSPA1A, HSPA1B, HSP90AA1, DNAJB1 (heat shock chaperones). This is a canonical immediate early gene + heat shock response module, broadly expressed across all glial subsets. The AP-1 + HSP combination is characteristic of dissociation stress or acute activation. However the remission-associated increase and uniform glial expression suggest in vivo activity. This is the broadest and most constitutively expressed stress/activation module in the neighborhood.
Genes
DNAJB1, EGR1, FOS, FOSB, HES1, HSP90AA1, HSPA1A, HSPA1B, IER2, JUN, JUNB, ZFP36
Most correlated modules
- Integrated Stress Response · correlation 0.95
- DNA Damage Response · correlation 0.92
- Integrated Stress Response · correlation 0.85
- Anti-proliferative mRNA Decay · correlation 0.84
- Glucocorticoid Stress Recovery · correlation 0.83
- Glial Progenitor Identity · correlation 0.78
- Hypoxia mTOR Stress · correlation 0.76
- Proteostasis Stress Response · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.