Integrated Stress Response
Gene co-expression module in Glial cells
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
All 11 genes are core members with ATF3 (integrated stress response TF), NR4A1 (immediate early nuclear receptor), KLF4 (stress-induced stemness TF), DUSP1 (MAPK phosphatase, stress-protective), SOCS3 (JAK/STAT inhibitor), MAFF (stress bZIP TF), HSPH1 and HSPA8 (heat shock chaperones), DNAJA1 (HSP40), SERTAD1 (CDK4 regulator), CCNL1 (cyclin). This is a canonical heat shock protein + immediate early transcription factor stress response module. ATF3, DUSP1, SOCS3, NR4A1 collectively define a cytoprotective/stress-mitigation program. Elevated expression (mean 1.029) and high pct positive (45.5%). Neighbor M24 (FOS/JUN/HSPs) is the broader immediate-early program; M50 is the ATF3-centered integrated stress response arm.
Genes
ATF3, CCNL1, DNAJA1, DUSP1, HSPA8, HSPH1, KLF4, MAFF, NR4A1, SERTAD1, SOCS3
Most correlated modules
- Integrated Stress Response · correlation 0.96
- DNA Damage Response · correlation 0.96
- Immediate Early Gene Response · correlation 0.95
- Glucocorticoid Stress Recovery · correlation 0.90
- Anti-proliferative mRNA Decay · correlation 0.87
- Proteostasis Stress Response · correlation 0.86
- COX-2/NF-κB Inflammation · correlation 0.86
- Inflammatory Activation Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.