Hypoxia mTOR Stress
Gene co-expression module in Glial cells
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
DDIT4 (REDD1) is a canonical hypoxia- and mTOR-stress gene that inhibits mTORC1; CITED2 is a transcriptional co-activator regulated by HIF-1α; HEXIM1 regulates P-TEFb/CDK9 transcriptional elongation; SRSF7 is an SR splicing factor; AMD1 is a key enzyme in polyamine biosynthesis; NEU1 is a lysosomal neuraminidase involved in glycoprotein catabolism; CDKN2AIP interacts with p14ARF/p53; INTS6 is part of the integrator complex regulating snRNA/Pol II; IFRD1 is a stress/differentiation response gene; RASD1 is a Ras-family GTPase; SOX4 is a developmental TF expressed in neural/glial cells; HSPA2 is a heat-shock protein. The dominant signal combines hypoxia-mTOR stress (DDIT4, CITED2), transcriptional regulation (HEXIM1, INTS6), and metabolic/stress genes. The strong decrease during UC inflammation suggests this is a homeostatic program suppressed in disease. Together with the neighboring M31 (integrated stress response) and M29 (inflammatory activation), this module appears to represent a hypoxia/mTOR-stress transcriptional program distinct from the acute stress response.
Genes
AMD1, CDKN2AIP, CITED2, DDIT4, HEXIM1, HSPA2, IFRD1, INTS6, NEU1, RASD1, SOX4, SRSF7
Most correlated modules
- Anti-proliferative mRNA Decay · correlation 0.89
- Glial Quiescence State · correlation 0.84
- Glial Progenitor Identity · correlation 0.83
- DNA Damage Response · correlation 0.81
- Glucocorticoid Stress Recovery · correlation 0.78
- Immediate Early Gene Response · correlation 0.76
- RNA Splicing Processing · correlation 0.72
- Integrated Stress Response · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.