Rho GTPase Signaling

Gene co-expression module in Glial cells

View this module in SCUBA

Why this annotation

Top hub genes include MORF4L1 (chromatin/NuA4 complex), MRFAP1 (MORF4L1-associated protein, regulates protein turnover), SKP1 (SCF ubiquitin ligase complex), RAC1 (Rho GTPase, cytoskeletal/signaling), RHOA (Rho GTPase), PRDX1 (peroxiredoxin, redox regulation), OAZ1 (ornithine decarboxylase antizyme, polyamine/protein turnover), NDFIP1 (Nedd4 family interacting protein, ubiquitin pathway), BRK1 (HSPC300, Arp2/3 activator complex), SF3B6/PUF60 (splicing factors), SCP2 (lipid transfer), GAPDH (glycolysis/housekeeping), COMMD6 (COMM domain, copper/NF-kB regulation). The module is dominated by general housekeeping functions: ubiquitin-proteasome pathway (SKP1, NDFIP1, OAZ1), Rho GTPase signaling (RAC1, RHOA, BRK1), and basic cellular maintenance. GAPDH and PRDX1 reinforce housekeeping character. The decrease in inflammation states and increase in remission is consistent with a constitutive/housekeeping program. Concordant genes for ubiquitin/proteasome/protein turnover: SKP1, NDFIP1, OAZ1, MRFAP1; cytoskeletal Rho signaling: RAC1, RHOA, BRK1; splicing: SF3B6, PUF60; general: GAPDH, PRDX1, MORF4L1, COMMD6, SCP2.

Genes

BRK1, COMMD6, GAPDH, MORF4L1, MRFAP1, NDFIP1, OAZ1, PRDX1, PUF60, RAC1, RHOA, SCP2, SF3B6, SKP1

Most correlated modules

• ER Membrane Homeostasis · correlation 0.96
• Mitochondrial OxPhos Integrity · correlation 0.95
• Antioxidant Stress Response · correlation 0.94
• ER-Mitochondria Housekeeping · correlation 0.94
• Nascent Polypeptide Translation · correlation 0.93
• ER Translocon Activity · correlation 0.91
• Mitochondrial Housekeeping · correlation 0.91
• Actin Cytoskeletal Organization · correlation 0.91

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.