Actin Cytoskeletal Organization
Gene co-expression module in Glial cells
| Category | Cytoskeletal |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
The module is anchored by DYNLL1 (dynein light chain), CFL1 (cofilin-1, actin severing), ACTB, and ACTG1 — core components of actin cytoskeletal dynamics. CALM1 (calmodulin) regulates actin-myosin interactions. YWHAQ (14-3-3 theta) scaffolds cytoskeletal signaling. PPIA (cyclophilin A) is a peptidyl-prolyl isomerase involved in cytoskeletal regulation and is also a known dissociation stress marker. CIRBP (cold-inducible RNA-binding protein) is a stress-induced RNA stabilizer. Multiple weak membership scores and moderate coherence suggest a mixed module blending cytoskeletal organization with a mild stress overlay. The neighbor context of M71 and M6 (translation and oxidative stress) supports that these modules collectively represent homeostatic programs suppressed during inflammation.
Genes
ACTB, ACTG1, CALM1, CFL1, CIRBP, DYNLL1, ELOC, MORF4L2, PPIA, YWHAQ
Most correlated modules
- Rho GTPase Signaling · correlation 0.91
- ER Membrane Homeostasis · correlation 0.90
- RNA Translation Processing · correlation 0.89
- Oxidative Stress Response · correlation 0.89
- Mitochondrial Housekeeping · correlation 0.88
- ER Stress Response · correlation 0.88
- Nascent Polypeptide Translation · correlation 0.86
- Mitochondrial OxPhos Integrity · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.