Antioxidant Stress Response
Gene co-expression module in Glial cells
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include SOD1 (superoxide dismutase), SELENOW (antioxidant selenoprotein), HSBP1 (heat shock protein binding), CSTB (lysosomal cystatin), and PLPP1 (lipid phosphatase). Together these reflect a cellular stress-protective / antioxidant homeostasis program. NDUFB11 links to mitochondrial function. Module is upregulated in UC remission, consistent with restoration of protective glial programs after inflammation resolves.
Genes
AP2S1, CSTB, DYNLRB1, HSBP1, MAGED2, NDUFB11, PLPP1, PPDPF, SELENOW, SOD1
Most correlated modules
- Rho GTPase Signaling · correlation 0.94
- Glial Vesicle Trafficking · correlation 0.94
- ER Membrane Homeostasis · correlation 0.91
- Glutathione Detoxification · correlation 0.90
- Mitochondrial OxPhos Integrity · correlation 0.89
- ER-Mitochondria Housekeeping · correlation 0.88
- Nascent Polypeptide Translation · correlation 0.85
- Actin Cytoskeletal Organization · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.