ER Membrane Homeostasis
Gene co-expression module in Glial cells
| Category | Neroprotection |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Top hub genes: SNCA (alpha-synuclein, neuronal vesicle trafficking/lipid membrane association, glial neuroprotection), VAPA (VAMP-associated protein A, ER-lipid droplet contacts, membrane tethering), GNAI2 (Gi-alpha-2, inhibitory G-protein signaling), LITAF (LPS-induced TNF-alpha factor, endosomal sorting/ubiquitin ligase), SARAF (store-operated calcium entry-associated regulatory factor, calcium signaling/ER), SBDS (ribosome biogenesis/Shwachman-Bodian-Diamond), YWHAH (14-3-3 eta, scaffold/signaling), RTN4 (Nogo/reticulon-4, ER morphology, axon growth inhibition — key glial gene), KHDRBS3 (RNA-binding protein, splicing/mRNA processing), SH3BGRL (SH3 domain-binding glutamic acid-rich-like, redox/thioredoxin). SNCA and RTN4 are notable glial/neuronal identity genes involved in membrane and ER dynamics. VAPA, SARAF, RTN4, and SNCA all converge on ER-membrane contact sites and lipid/calcium homeostasis. GNAI2 and YWHAH add G-protein and scaffold signaling. Decreased in CD inflammation, increased in UC remission — suggests a constitutive glial neuroprotective/homeostatic membrane program. Neighbor context: sits near ER-focused modules (M32, M54), consistent with membrane/ER lipid contact site theme.
Genes
GNAI2, KHDRBS3, LITAF, RTN4, SARAF, SBDS, SH3BGRL, SNCA, VAPA, YWHAH
Most correlated modules
- Rho GTPase Signaling · correlation 0.96
- ER-Mitochondria Housekeeping · correlation 0.92
- Antioxidant Stress Response · correlation 0.91
- Mitochondrial OxPhos Integrity · correlation 0.90
- Actin Cytoskeletal Organization · correlation 0.90
- ER Translocon Activity · correlation 0.87
- Glial Vesicle Trafficking · correlation 0.85
- Mitochondrial Housekeeping · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.