Mitochondrial OxPhos Integrity
Gene co-expression module in Glial cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes: PARK7 (DJ-1, mitochondrial redox sensor, neuroprotection against oxidative stress, Parkinson's-linked), HINT1 (histidine triad nucleotide-binding protein, mitochondrial/apoptosis), CHCHD2 (MINOS complex/intermembrane space, mitochondrial cristae/OxPhos regulation, Parkinson's-linked), COX6B1 (Complex IV cytochrome c oxidase subunit), TMEM14C (mitochondrial inner membrane protein, heme biosynthesis), ATP5MC3 and ATP5PF (ATP synthase subunits, Complex V), RBX1 (SCF ubiquitin ligase RING-box, proteasome substrate targeting), UBL5 (ubiquitin-like modifier, mitochondrial pre-mRNA splicing). This is a tightly coherent (core) module dominated by mitochondrial OxPhos (COX6B1, ATP5MC3, ATP5PF, CHCHD2) with a notable neuroprotective/redox angle via PARK7 and CHCHD2 (both Parkinson's disease-associated mitochondrial proteins). The combination of OxPhos subunits with PARK7/CHCHD2 specifically suggests mitochondrial integrity maintenance in glia. Neighbor context: adjacent to M32 (OxPhos/ER) reinforcing the mitochondrial neighborhood.
Genes
ATP5MC3, ATP5PF, CHCHD2, COX6B1, HINT1, PARK7, RBX1, TMEM14C, UBL5
Most correlated modules
- ER Translocon Activity · correlation 0.96
- Rho GTPase Signaling · correlation 0.95
- ER-Mitochondria Housekeeping · correlation 0.95
- Nascent Polypeptide Translation · correlation 0.93
- Proteasomal Proteostasis · correlation 0.93
- Mitochondrial Housekeeping · correlation 0.92
- Proteostasis Stress Response · correlation 0.92
- Glutathione Detoxification · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.