SCUBA

SKP1 — S-phase kinase associated protein 1

SKP1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SKP1's module in each cell type

Cell typeModuleShares the module with
Gamma-delta T cellsAnabolic Activation Response
Housekeeping		ABHD5, ATF4, ATP6V0C, ATP6V1G1, BCL7B, BUD31, CALM2, CHRAC1 +26 more
Glial cellsRho GTPase Signaling
Housekeeping		BRK1, COMMD6, GAPDH, MORF4L1, MRFAP1, NDFIP1, OAZ1, PRDX1 +5 moreView in SCUBA
Innate lymphoid cellsMitochondrial Housekeeping
Mitochondrial & OxPhos		COX7A2, COX7B, EEF1B2, EIF1AX, FTH1, HNRNPC, ID2, NAP1L1 +8 moreView in SCUBA
Lymphatic endothelialProtein Quality Control
Protein processing & ER		BCAP29, CD99, CDC42, DYNLRB1, GNG5, NDUFV2, PDCD6, PFDN5 +1 moreView in SCUBA
MacrophagesMixed Housekeeping
Housekeeping		AP2M1, BAG1, CHMP4A, CISD2, COA6, CSNK2B, CYB5R3, DEGS1 +20 moreView in SCUBA
Mucosal-associated invariant T cellMitochondrial OxPhos
Mitochondrial & OxPhos		ATP5MF, H2AZ1, H4C3, INO80E, LYPLA2, NDUFA3, NDUFB1, SEM1 +3 more
Natural Killer cellsTGF-beta Repression
DNA regulation & transcription		BZW1, GTF2B, HBP1, ODC1, POLR2K, SKIL, SPTY2D1, UBE2D3View in SCUBA
Smooth muscle cellsOxPhos & proteasome
Mitochondrial & OxPhos		CD151, CHCHD2, COX5B, EID1, NDUFA11, NDUFB2, NDUFB9, NEDD8 +8 moreView in SCUBA

About the gene

SynonymsEMC19, MGC34403, OCP-II, OCP2, p19A, SKP1A, TCEB1L
Chromosome5: 134148935-134176964
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Predicted intracellular proteins
Biological processHost-virus interaction, Ubl conjugation pathway

Function

Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Core component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Also acts as a core component of the Cul1- RING(FBXL4) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of BNIP3 and BNI3L.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.