Reactive Glial Activation
Gene co-expression module in Glial cells
| Category | Activation |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include F2R (PAR-1/thrombin receptor, inflammation and coagulation signaling), FN1 (fibronectin, ECM/repair), PRSS23 (serine protease), AEBP1 (transcriptional repressor, fibrosis-associated), EEA1 (endosomal trafficking), PSMA4 (proteasome), IFI16 (innate immune sensor), ATP5F1E and POLR2L (housekeeping). Strong upregulation in UC inflammation (delta=0.511). F2R, FN1, and AEBP1 together point to a reactive/fibrotic glial or stromal activation state. IFI16 adds an innate immune sensing component. The combination of coagulation/protease signaling (F2R, PRSS23), matrix (FN1, AEBP1), and immune sensing (IFI16) suggests an inflammation-driven tissue remodeling/activation response. In the context of colonic glia, this likely reflects reactive gliosis with ECM remodeling during active IBD. Neighbor context: fits well within the inflammatory network seen in M2, M28, M72, M73.
Genes
AEBP1, ATP5F1E, EEA1, F2R, FN1, IFI16, POLR2L, PRSS23, PSMA4
Most correlated modules
- Proteostasis Stress Response · correlation 0.90
- Proteasomal Proteostasis · correlation 0.89
- ER Translocon Activity · correlation 0.88
- MHC-I Antigen Presentation · correlation 0.85
- TGF-beta ECM Remodeling · correlation 0.84
- Type I/II Interferon Response · correlation 0.82
- ER-Mitochondria Housekeeping · correlation 0.81
- Mitochondrial OxPhos Integrity · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.