Proteasomal Proteostasis
Gene co-expression module in Glial cells
| Category | Protein processing & ER |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes: PSMB1 and PSMB3 (proteasome beta subunits, 20S core), PSMA7 (proteasome alpha subunit, 20S core), CD63 (lysosomal/late endosomal tetraspanin, autophagy/exosome marker), S100A11 (calcium-binding protein, inflammatory/cytoskeletal), COX7A2 (Complex IV subunit), CLIC1 (chloride intracellular channel, cell volume/stress), MYL12B (myosin regulatory light chain, cytoskeletal), SELENOM (selenoprotein M, ER/redox), PDIA6 (protein disulfide isomerase, ER quality control), ELOB (elongin B, ubiquitin E3 ligase), SERF2 (small EDRK-rich factor, amyloid/chaperone). The dominant signal is proteasomal degradation (PSMB1, PSMB3, PSMA7) combined with lysosomal trafficking (CD63) and ER quality control (PDIA6, SELENOM) — a coordinated protein quality control/proteostasis program. ELOB adds ubiquitin E3 ligase activity upstream. S100A11 and CLIC1 suggest some inflammatory overlay. Core coherence and high pct positive indicate a constitutive housekeeping proteostasis program in glia.
Genes
CD63, CLIC1, COX7A2, ELOB, MYL12B, PDIA6, PSMA7, PSMB1, PSMB3, S100A11, SELENOM, SERF2
Most correlated modules
- ER Translocon Activity · correlation 0.94
- Mitochondrial OxPhos Integrity · correlation 0.93
- Proteostasis Stress Response · correlation 0.93
- Nascent Polypeptide Translation · correlation 0.89
- Reactive Glial Activation · correlation 0.89
- Glutathione Detoxification · correlation 0.88
- ER-Mitochondria Housekeeping · correlation 0.86
- Mitochondrial Housekeeping · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.