Basement Membrane Adhesion
Gene co-expression module in Glial cells
| Category | ECM remodeling |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes ANTXR2 (anthrax toxin receptor 2, binds collagen IV and laminin in basement membrane), ITGAV (integrin αV, mediates ECM adhesion via RGD motifs), DMD (dystrophin, links actin cytoskeleton to ECM at the membrane), CHL1 (L1 family cell adhesion molecule), GPC1 (glypican-1, heparan sulfate proteoglycan anchored to ECM), and PRIMA1 (membrane anchor for acetylcholinesterase at synaptic basal lamina) all point to a basement membrane/ECM adhesion program. TMEM123 is membrane-associated. This module reflects glial anchorage to and interaction with the perisynaptic/perivascular ECM.
Genes
ANTXR2, C2orf88, CHL1, DMD, GPC1, ITGAV, PRIMA1, TMEM123
Most correlated modules
- Peripheral Nerve Myelination · correlation 0.89
- Actin Remodeling Migration · correlation 0.88
- Glial Homeostatic Identity · correlation 0.86
- Glial Cytoskeletal Homeostasis · correlation 0.83
- Glial RNA Homeostasis · correlation 0.81
- Glial Identity Homeostasis · correlation 0.81
- Lysosomal Sphingolipid Metabolism · correlation 0.78
- Glial Neuroprotective Response · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.