SEMA3C — Semaphorin 3C
SEMA3C belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEMA3C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | YAP cytoskeletal remodeling Migration & adhesion | ABLIM1, AHCYL2, ARHGAP26, CCSER1, CDC42BPA, FGD4, ITGB8, PDE4D +5 more | View in SCUBA |
| Fibroblasts | PI16+ Fibroblast Identity ECM production | AADACL2, ADAMTSL4, ARHGAP29, C16orf89, CADM3, CD248, CLEC3B, CYP4B1 +10 more | View in SCUBA |
| Glial cells | Glial Homeostatic Identity Development | GAS7, NUCKS1, QKI, SIPA1L2, SORCS1, TMEM245, VCL, ZBTB20 | View in SCUBA |
| Macrophages | SPP1 Tissue Remodeling ECM remodeling | BST1, CD52, CHI3L1, CHIT1, CSF1, FBP1, FGR, FN1 +19 more | View in SCUBA |
| Smooth muscle cells | Collagen-Laminin Deposition ECM remodeling | COL5A1, COL5A2, COL6A3, LAMA4, LAMB1, NEGR1, PARVA, PCDH7 +4 more | View in SCUBA |
About the gene
| Synonyms | SEMAE, SemE |
|---|---|
| Chromosome | 7: 80742538-80922359 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Neurogenesis |
Function
Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.